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What are glipizide tablets?

GLIPIZIDE (Glucotrol reg;) helps to treat type 2 diabetes mellitus. Treatment is combined with diet and exercise. Glipizide increases the amount of insulin in the blood. Glipizide helps your body to use insulin more efficiently. Generic glipizide tablets are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

kidney disease
liver disease
major surgery
severe infection or injury
thyroid disease
an unusual or allergic reaction to glipizide or other sulfonylureas, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I take this medicine?

Take glipizide tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If you take glipizide once a day, take it 30 minutes before breakfast. Do not take with food. Take your doses at the same time each day; do not take more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with glipizide?

alcohol
beta-blockers (used for high blood pressure or heart conditions)
bosentan
cisapride
clofibrate
diazoxide
medicines for fungal or yeast infections (examples: fluconazole, itraconazole, miconazole, voriconazole)
metoclopramide
rifampin
warfarin (a blood thinner)

Many medications may cause changes (increase or decrease) in blood sugar, these include:

alcohol containing beverages
aspirin and aspirin-like drugs
beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)
chromium
female hormones, such as estrogens or progestins, birth control pills
isoniazid
male hormones or anabolic steroids
medications for weight loss
medicines for allergies, asthma, cold, or cough
niacin
pentamidine
phenytoin
quinolone antibiotics (examples: ciprofloxacin, levofloxacin, ofloxacin)
some herbal dietary supplements
steroid medicines such as prednisone or cortisone
thyroid hormones
water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking glipizide?

Side effects that you should report to your prescriber or health care professional as soon as possible:

hypoglycemia (low blood glucose) which can cause symptoms such as anxiety or nervousness, confusion, difficulty concentrating, hunger, pale skin, nausea, fatigue, perspiration, headache, palpitations, numbness of the mouth, tingling in the fingers, tremors, muscle weakness, blurred vision, cold sensations, uncontrolled yawning, irritability, rapid heartbeat, shallow breathing, and loss of consciousness.
breathing difficulties, severe skin reactions or excessive phlegm, which may indicate that you are having an allergic reaction to the drug.
dark yellow or brown urine, or yellowing of the eyes or skin, indicating that the drug is affecting your liver.
fever, chills, sore throat; which means the drug may be affecting your immune system.
skin rash, redness, swelling or itching
unusual bleeding or bruising; which occurs when the drug is affecting your blood clotting system.

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

diarrhea
headache
heartburn, stomach discomfort
increased sensitivity of the skin to the sun
nausea, vomiting

What should I watch for while taking glipizide?

Visit your prescriber or health care professional for regular checks on your progress. Learn how to monitor blood or urine sugar and urine ketones regularly. Check with your prescriber or health care professional if your blood sugar is high, you may need a change of dose of glipizide. Do not skip meals. If you are exercising much more than usual you may need extra snacks to avoid side effects caused by low blood sugar. Alcohol can increase possible side effects of glipizide. Ask your prescriber or health care professional if you should avoid alcohol. If you have mild symptoms of low blood sugar, eat or drink something containing sugar at once and contact your prescriber or health care professional. It is wise to check your blood sugar to confirm that it is low. It is important to recognize your own symptoms of low blood sugar so that you can treat them quickly. Make sure family members know that you can choke if you eat or drink when you have serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.

Glipizide can increase the sensitivity of your skin to the sun. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths.

If you are going to have surgery, tell your prescriber or health care professional that you are taking glipizide.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

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